Oral communication, CS3 / C11

Official XXIst International Pigment Cell Conference website - 21-24 Sept 2011, Bordeaux - France | updated: September 04 2011

Epidemiological, clinical & histopathological profile and patch test results in patients of Primary Localized Cutaneous Amyloidosis(PLCA)

INTRODUCTION AND OBJECTIVES: We carried this project to: 1. study epidemiological and clinical profile of PLCA, 2. to compare findings of histopathology, Thioflavin-T & DIF and, 3. to evaluate the photopatch test results in these patients. MATERIALS AND METHODS: Patients of clinical diagnosis of PLCA were included in the study.History & clinical examination was followed by histopathological evaluation of skin biopsies and then patch testing with antigens of universal and cosmetic series.Amyloid deposits along with features like dilated dermal papillae, pigmentary incontinence and increased melanin in basal layers for H&E, Yellowish green deposits of amyloid in papillary dermis for Thioflavin-T & fluorescent deposits in papillary dermis for DIF were considered diagnostic of PLCA. OBSERVATIONS AND RESULTS: Mean age of presentation was 38.76 years with female preponderance. Diabetes was seen in 20% of patients. History of Itching and friction was present in 78.46% and 76.92% of patients respectively. Macular type (84.61%) was present on the back and arms. Lichen (50%) on the legs and biphasic (6%) at combined sites. Amyloid was demonstrated by H&E in (63.07%), Thioflavin-T in (64.61%) and DIF in (44.61%) of cases with best results on the legs. Patch test positivity was found in 6 patients. CONCLUSIONS: PLCA is a common pigmentary dermatosis in Indian population with friction and itching as inciting factors. H&E stain was found equally effective in demonstration of amyloid compared to newer stains.

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