Oral communication, iL23

Official XXIst International Pigment Cell Conference website - 21-24 Sept 2011, Bordeaux - France | updated: September 04 2011

How does solar UV radiation initiate specific cellular responses?

SPEAKER M.-D. Galibert #whois submiter ?
AUTHOR(s) M.-D. Galibert

The Sun is required and responsible for the development and continued existence of life on Earth, although it triggers deleterious side effects. The skin the most exposed body organ is constantly challenged by ultraviolet rays that comprise UVA (400-320 nm), UVB (320-290 nm), and in particular circonstances UVC (290-200 nm). UV rays monitor specific skin responses, based on the wavelength, with shorter wavelength being more photobiologically active, the UV-dose and the duration of the exposure (acute versus chronic). Skin exposure to solar radiation will thus initiates complex and specific molecular processes. These include the protective tanning response, local inflammation, immune suppression, and DNA damage that can lead to skin carcinogenesis. Understanding how transcription factors interpret the UV output from signal transduction pathway to drive distinct programs of gene expression is a key issue that is still under investigation and will lead to decipher disease development.



Advertisement from our sponsor:
Astellas Pharma Worldwide

Université de Bordeaux 2 & Conseil Régional Aquitaine