Poster presentation, P81

Official XXIst International Pigment Cell Conference website - 21-24 Sept 2011, Bordeaux - France | updated: September 04 2011

Study of oxidative stress in vitiligo

SPEAKER V. Mendiratta #whois submiter ?
AUTHOR(s) V. Mendiratta, J. Mal

BACKGROUND: Recent studies bring to light putative role of oxidative stress generated by reactive oxygen species in causing destruction of melanocytes in vitiligo. AIM: Estimation of serum levels of superoxide dismutase (SOD) and Glutathione peroxidase (GPx) in vitiligo. STUDY DESIGN: Cross sectional, investigative, case control study. PATIENTS AND METHODS: 100 subjects (> 15 years) were recruited for the study. Group 1 had 50 untreated patients with active vitiligo. Group 2 had 25 patients of stable vitiligo and 25 healthy controls who fulfilled the inclusion criteria. All were subjected to detailed history, blood investigations, thyroid function test, antinuclear antibody and rheumatoid factor assay. Estimation of superoxide dismutase activity, Glutathione peroxidase (PAGLIA and Valentine method) was performed in all. RESULTS: Vitiligo affected (16-25 years) age group in 54%. M:F ratio was 1:2.13. V. vulgaris was the commonest (52%).Onset was at 11-20 yrs in 44%. Family history was noted in 10%. Raised TSH levels were noted in 10% of the active vitiligo cases only. Mean value of (SOD) was 367 U/ml in active vitiligo, followed by 300 U/ml in vitiligo controls and lowest (237 U/ml) in healthy controls. Mean value for Glutathione peroxidase was (4011 U/ml) in active vitiligo, (3990 U/ml) in vitiligo controls and (3945 U/ml) in healthy controls. CONCLUSIONS: Level of superoxide dismutase (SOD) were significantly higher in active vitilgo as compared to controls. The present study reflects a fascilitatory role of oxidative stress in activity of vitiligo. Glutathione peroxidase levels showed an inconsistent pattern.



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