Poster presentation, P78

Official XXIst International Pigment Cell Conference website - 21-24 Sept 2011, Bordeaux - France | updated: September 04 2011

Comparison of efficay and side effect profile of oral PUVA versus oral PUVA sol in the treatment of vitiligo: a 36 week prospective study

BACKGROUND: Both Oral PUVA and PUVA sol have been successfully used in vitiligo treatment. However, there is paucity of studies comparing the two therapies, especially under conditions of abundant sunlight where PUVA sol is more feasible. OBJECTIVES: To compare the efficacy and side effects of oral PUVA versus oral PUVA sol therapy in generalized vitiligo. METHODS: Comparative prospective clinical trial conducted on consecutive patients of generalized vitiligo allocated to either oral PUVA or PUVA sol groups treated for period of 36 weeks. Response to treatment was assessed using change in Lund & Browder (L & B) score for assessment of reduction in body surface area of involvement, patient global assessment (PGA) of improvement in vitiligo, investigator’s global assessment (IGA) of extent of repigmentation, and quality of life (QOL) assessment using Tjioe et al questionnaire. RESULTS: Thirty five patients were recruited - 18 in PUVA and 17 in PUVA sol group. Mean percentage change in L & B score at 36 weeks was 46.4% in PUVA and 26.1% in PUVA sol group (p = 0.06), mean PGA score in PUVA was 4.58 and in PUVA sol group was 6 (p = 0.13), mean IGA score was 3.08 in PUVA and 1.79 in PUVA sol group (p = 0.11). QOL scores were significantly higher in PUVA group as compared to the PUVA sol group (p = 0.04). Side effects were comparable in two groups except for phototoxicity which was significantly more in PUVA group. CONCLUSIONS: PUVA is more efficacious than PUVA sol and also provides greater psychological benefit in treatment of generalized vitiligo but is associated with more phototoxic adverse effects.

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